ASSOCIATION OF TELOMERE WITH AGEING THROUGH CELLULAR SENESCENCE AND MITOCHONDRIAL MALFUNCTION

Abstract

Marked by a progressive decline in the function of tissues and organs that ultimately results in death,Aging is a
biological conditionTelomeres, are repetitive DNA sequences necessary for cell fate and aging. Telomeres
shorten when cells mature, resulting in cellular senescence and mitochondrial dysfunction.. “Cellular senescence
and mitochondrial malfunction” will then result in organ or tissue degeneration and dysfunction, as well as a
variety of somatic ageing mechanisms. We summarized the relationship between cell senescence, mitochondrial
dysfunction, and aging in this paper.