A STUDY OF ALTERED THYROID HORMONES METABOLISM IN ALCOHOLIC LIVER DISEASES: AN ANALYTICAL STUDY
DOI:
https://doi.org/10.48047/Keywords:
ALD, BMI, ADVIA Centaur XP, T3, T4, TSH, TRH.Abstract
Alcoholic Liver Disease (ALD) is among one of the ten most common causes of deaths
worldwide. Liver the largest gland in the body is a major site of thyroid hormones peripheral
metabolism and is involved in its conjugation, biliary excretion, oxidative deamination and
extrathyroidal deiodination of T4 to T3. In most chronic hepatic illnesses defects arise in
thyroid hormone metabolism resulting in sick euthyroid syndrome. The above functions of
liver are impaired in chronic liver diseases leading to decrease in T3, T4 and altered TSH
levels. Some patients with chronic liver diseases may have thyroiditis, hyperthyroidism or
hypothyroidism through autoimmune mechanisms. The exact mechanisms behind this is not
well understood and hence the present study.
