Cardioprotective effect of alcohol extract and seed powder dietary supplementation of quinoa (Chenopodium quinoa) in female rats treated with Doxorubicin

Abstract

Doxorubicin (DOX) is an anthracycline drug used for different type of cancer treatment related to
many toxic systemic effects. We examined the cardioprotective potential of Chenopodium quinoa
against DOX cardiotoxicity. 30 female Sprague Dawley rats were randomly assorted into 6 groups.
Control group I: received normal saline with standard rat feed and water ad libitum; DOX group II:
received 15 mg/kg b.w. dosage of single intraperitoneal DOX on the eighth day of the 21-day
experiment period. Co-treatment groups III, IV and V: received 300 mg/kg b.w. of quinoa seeds
ethanol extract, different percentages of (20 and 40%) of dietary supplementation with quinoa seeds
powder (QSP) were given orally throughout the trial period in concomitant with single intraperitoneal
DOX as in DOX group II respectively. Standard group VI: received vitamin C 250 mg/kg b.w daily as
in co-treatment groups. Phytochemical screening and antioxidant activity of quinoa seeds, Biochemical
changes and oxidative stress markers in serum and heart tissue extract were examined. DOX caused
significant increase in serum LDH and CK activity and lower antioxidant enzymes in serum and heart
tissue. Quinoa seed ethanol extract and dietary supplementation with quinoa seed powder ameliorates
DOX-prompted changes in serum and tissue heart by enhancing antioxidant enzyme activities. Quinoa
seeds possesses a majority of phytochemical classes of compounds . Our results suggest that cotreatment of QSP dietary supplementation markedly improve DOX-induced heart deleterious effects.
The potency of co-treatment of QSP dietary supplementation at 40% is similar to vitamin C. These
results revealed that dietary supplementation with quinoa seed powder might serve as a potential
adjuvant that avoids DOX-induced cardiotoxicity