Prevalence of H pylori among patients with Mitral Valve prolapse

Abstract

Helicobacter pylori is one of a pathogenic bacteria that prevalent a wide on the world ,It is found around 50%
from population in different region , it is colonized on stomach ,it is have ability to adapted itself to acidic media
on it , ,It is responsible of many gastric cancer Colorectal cancer ,Ulcers ,Gastritis and have an important role in
increased severity of Chronic disease such as Diabetic ,Autoimmune ,Coronary Heart diseases and Arthrosclerosis
.In this current study ,We are working to study a prevalence H pylori in M VP patients by three methods ,estimate
INF-γ & IL-6 ,detect genes .At first ,All participation patients are from the gastro-intestinal and Cardiology
department of Al Fallujah General Hospital and Al Ramadi General Hospital , From period 1st September in 2020 to
1
st
 April 2021 .A total of cases are 100 case ,50 case with Mitral Valve prolapse (pre-diagnosed with Mitral Valve
Prolapse) ,Other 50 case are normal patients used as a control, their ages range from 10 to 70 year .All patients are
suffered from gastric inflammation ,bloating ,nausea and burping, All patients don‘t have any drugs before tested.
The diagnosis by three method , estimate INF-γ ,IL-6 by ELISA , All positive stool in MVP kept deep freezing for
gene detect by Real Time PCR. The results are in SAT and U B T (identical result), positive in M V P patients high
than N patients, Urban are a high positive results than urban. While in S Ab T are high positive in MVP than N
patients ts. Also the results are positive in INF-γ and IL-6 are high values in MVP than N patients .the results of
detect H pylori genes by real time PCR , 16sr RNA gene is positive for all MVP only, Cag-A gene is (12) positive
(54%) , Vac A gene is (6) positive (27.5%)