Perioperative Use of Dexmedetomidine in General Anesthesia: A CrossSectional Analysis

Abstract

Background: Dexmedetomidine, a highly selective α2-adrenergic agonist, has gained attention for its
versatile pharmacological properties in perioperative management. This study aimed to explore its
utilization in general anesthesia through a cross-sectional analysis. General anesthesia traditionally
relies on agents like opioids and benzodiazepines, associated with adverse effects. Dexmedetomidine's
sedative, analgesic, and anxiolytic properties make it an appealing adjunct.
Methods: This analysis assessed its frequency of use, indications, dosing, effectiveness, and barriers
to implementation among 500 respondents, including anesthesiologists and perioperative healthcare
providers.
Results: Results showed varied utilization across surgical specialties, with orthopedic surgery most
common. Dexmedetomidine was frequently used for intraoperative analgesia, anxiolysis, and
sedation, particularly in orthopedic and neurosurgical procedures. Dosing varied by specialty, with
higher doses for cardiac surgery. Perceived effectiveness was high, with reported reductions in opioid
use and improved hemodynamic stability. Barriers included concerns about hemodynamics and
familiarity with dosing.
Conclusion: Tailoring dexmedetomidine use to specific specialties and addressing barriers is essential
for optimizing perioperative care. This analysis contributes to understanding dexmedetomidine's role
and informs evidence-based practice.