Prospective Study on the Occurrence of Adverse Ideation Events in Relatives of Patients with Obsessive-Compulsive Disorder

Abstract

Introduction: Obsessive-Compulsive Disorder (OCD) is a chronic and debilitating mental
health condition characterized by intrusive thoughts and repetitive behaviors. It is widely
recognized that OCD has a genetic component, with first-degree relatives of patients showing
a higher risk of developing the disorder. Adverse Ideation Events (AIEs), distressing thoughts
not directly related to OCD symptoms, are also reported but less studied within this population.
Understanding the occurrence and impact of AIEs alongside OCD in relatives could advance
the identification and treatment approaches for these conditions.
Methodology: This two-year prospective study involved 100 participants who were firstdegree relatives of patients receiving OCD treatment at a specialized outpatient clinic.
Assessments were conducted at baseline, one year, and two years, using the Structured Clinical
Interview for DSM-5 (SCID-5), the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), and
the Adverse Ideation Events Scale (AIES).
Results: Prevalence of OCD: Increased from 20% at baseline to 25% at the study's end. The
severity of OCD Symptoms: Mean Y-BOCS scores rose from 18 to 22, indicating increased
severity. Occurrence of AIEs: Reporting increased from 30% at baseline to 50% by study end.
Conclusion:
The findings highlight the critical need for comprehensive mental health strategies that address
both direct and vicarious experiences of OCD within affected families, emphasizing early
detection and intervention to improve overall outcomes.