Study of Lipid Profile in Cirrhosis of Liver Patients

Abstract

Cirrhosis is defined anatomically as a diffuse process with fibrosis and nodule formation. It is
the result of the fibrogenesis that occurs with chronic liver injury. For reduced liver
biosynthesis capacity, low level of triglyceride and cholesterol is usually observed in the
chronic liver disease. Due to the high prevalence of chronic liver disease in our country we
have conducted this study to determine lipid profile in a patient with cirrhosis. Total 50
patients of liver cirrhosis either male or female and having age from 18-65 years were
recruited. Fasting blood samples of all the patients were taken and sent to laboratory for lipid
profile. Total Cholesterol, LDL-Cholesterol, VLDL-Cholesterol, HDL-Cholesterol,
Triglycerides were low in cirrhosis patients as compared to normal control group. This
difference was statistically highly significant. Dyslipidemia is a common finding in chronic
liver disease. In chronic liver disease due to decreased biosynthetic capacity of liver
unusually low level of cholesterol, triglyceride, HDL and VLDL found.