Local drug delivery agents- An ever evolving paradigm in Non-surgical Periodontal therapy

Abstract

Non-surgical periodontal therapy is pivotal in managing periodontal diseases, aiming to 
eliminate bacterial biofilms and reduce inflammation. Local drug delivery agents have 
emerged as promising adjuncts to mechanical debridement, aiming to enhance treatment 
outcomes. This review provides a comprehensive overview of the evolution, mechanisms, 
clinical applications, current challenges, and future directions of local drug delivery agents in 
non-surgical periodontal therapy. From first-generation to third-generation systems, local 
drug delivery has evolved to offer targeted and personalized therapy, addressing microbial 
pathogens and host immune responses.