Effect Of Long Term Time Restricted Feeding On Anthropometry And Metabolic Characteristics, Hba1c, Crp; A Case Control Study

Abstract

Objective: An observational study was planned to observe the effects of long-term time
restricted feeding (LTRF) on the anthropometric HbA1c, FBS and CRPin the study population.
Material & Methods: The above study was conducted in the Dept. of Physiology, G. R.
Medical College and JA Group of Hospitals, Gwalior (M.P.), the study period was from
October 2019 to September 2020 (Data Collection Time.A total of 60 subjects in the age group
30-60 years were taken of which cases were 30 normal healthy individuals practicing Long
Term Time Restricted Feeding (LTRF group, feeding period of 10 hours and fasting period of
14 hours and practicing LTRF for > 3 years) and controls were 30 normal healthy individuals
age and sex-matched not practicing Time Restricted Feeding (NTRF group, fasting period <12
hours a day). Anthropometric parameters, weight & height were recorded and BMI and waisthip ratio were calculated. Metabolic parameters, HbA1c were tested along with the
inflammatory marker; quantitative C-reactive protein (CRP).An independent t-test was used as
a main statistical tool. Statistical analysis was done using SPSS software. P-value <0.05 was
considered a significant value.
Results:Anthropometric parameters naming body weight in LTRF group was 66.31 ± 7.74 Kg
and in NTRF group was 71.87 ± 10.27 Kg with P-value 0.021. BMI in LTRF group was 23.67
± 2.23 Kg/m2
and in NTRF group was 25.35 ± 2.96 Kg/m2 with P-value 0.017.Waist-hip ratio
in LTRF group was 0.852 ± 0.07 and in NTRF group was 0.89 ± 0.08 with P-value 0.035.
Biochemical parameters including HbA1c in the LTRF group was 5.22 ± 0.39 % and in NTRF
group was 5.54 ± 0.62 % with P-value of 0.022.CRP in the LTRF group was 1.95 ± 1.14 mg/L
and in NTRF group was 3.44 ± 2.37 mg/L with P-value of 0.003.
Conclusion:LTRF as a lifestyle could be a novel method to improve health, decrease
comorbidities associated with obesity and other lifestyle diseases.