BENZOTHIAZOLE ANALOGUES: POTENT ANTICANCER AGENTS IN CONTEMPORARY PHARMACEUTICAL RESEARCH

Abstract

Cancer encompasses a diverse group of disorders characterized by uncontrolled proliferation
of abnormal cells, which can originate in any organ or tissue of the body. The process of
metastasis, where cancer cells spread to distant organs, significantly contributes to cancerrelated mortality. Cancer is also referred to commonly as neoplasm or malignant tumor.
In 2018, cancer accounted for approximately 9.6 million deaths globally, making it the
second leading cause of death. Benzothiazole, a significant class of pharmaceutical
compounds, exhibits a wide array of biological activities, including antibacterial,
anticonvulsant, anticancer, antifungal, antimitotic, and antitumor properties. Benzothiazole
and its derivatives, such as the indole ring, have demonstrated promising anticancer activities.
Studies on structure-activity relationships of benzothiazole derivatives have provided
valuable insights into their efficacy against various cancer cell lines, enhancing our
understanding of their potential in cancer therapy.