COMPARISON OF CLONIDINE AND DEXMEDETOMIDINE FOR ATTENUATION OF HAEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION IN VALVULAR HEART SURGERY

Abstract

contribution to patient care, but the procedure results in changes of various hemodynamic parameters. The 
aim of study was to access the efficacy of Clonidine and Dexmedetomidine in blocking the cardiovascular 
response to laryngoscopy and intubation and ensuring stable hemodynamics. 
METHOD-A randomized , double blind, comparative study was conducted with  patients divided 
randomly into two groups, Group Clonidine and Group Dexmedetomidine. Baseline parameters of the 
patients were recorded before drug administration .Injection Etomidate 0.4 mg\kg i.v slowly followed by 
Injection Rocuronium 1.5mg\kg i.v  given . Hemodynamic parameters NIBP,HR , SPO2 measured after 
intubation 1,3,5,7,10 min. 
RESULT- Hemodynamic parameters were increased just after laryngoscopy and intubation compared to 
baseline. After few minutes hemodynamic parameter were stabilized. 
CONCLUSION-   Clonidine and Dexmedetomidine blunts the hemodynamic response to endotracheal 
intubation in patients undergoing valvular heart surgery under general anesthesia and can be safely used 
at induction of general anesthesia. Dexmedetomidine shows more attenuated pressure response to 
laryngoscopy and intubation compared to Clonidine.