A comparative study to evaluate the efficacy of vaginal versus oral prostaglandin E1 analogue (Misoprostol) in the management of firsttrimester missed abortions at a tertiary centre

Abstract

Background: Missed miscarriages in the first trimester are characterised by the arrest of embryonic or foetal development 
with ultrasound findings of an empty gestational sac or an embryo or foetus without cardiac activity.
Methods: Comparing the efficacy of misoprostol, by vaginal and oral routes, for termination of first trimester missed 
abortion was conducted in the department of obstetrics and gynaecology. 2 groups were made as group A and group B which 
had 60 participants in each group and a total of 120 participants, in which group A was given misoprostol 400 mcg orally, 
maximum up to 3 doses and group B was given misoprostol 400 mcg vaginally maximum up to 3 doses and outcome was 
documented. Primary outcome expecting drug induced complete expulsion of products of conception (POCs). Secondary 
outcomes measured were induction expulsion interval, number of doses required, classification of failures, cervical canal 
permeability in women requiring surgical evacuation, side effects.