A retrospective analysis of pyogenic liver abscess and antibiotic Susceptibility of common pathogens at a tertiary centre

Abstract

Background: Pyogenic liver abscess is a life-threatening disease with high morbidity and mortality. The aim was to investigate the common pathogens and discern the clinical features and microbiological characteristics of PLA more broadly, as well as to identify the most suitable antibiotics for the prevention and treatment of PLA.
Materials and Methods: The present retrospective observational study consisted of 80 male patients diagnosed with pyogenic liver abscesses. The study was evaluated based on history-taking and clinical examination. The medical and microbiological records of all the PLA patients who were hospitalized and treated at NMCH, Patna, were retrospectively reviewed. Demographic data and medical information were also retrospectively collected.
Results: Males were more commonly affected than females. The mean age of the study patient was 46±16.50 years, and the P value was 0.02 (significant). The mean length of hospital stay was 14.27 ± 4.61 days, and the P value was <0.001 (significant). In our current study, K. pneumoniae and E. coli were the most common pathogens causing pyogenic liver abscess, affecting 65% and 15% of patients, respectively. The most common lobe affected in liver abscesses was the right hepatic lobe (76.25%). Both gender and size of liver abscess between 5 and 10 cm were common.
Conclusion: Needle aspiration under USG is done for small abscesses (≤200 ml), whereas percutaneous drainage with pigtail catheter placement was done for large abscesses (>200 ml) under USG guidance were most effective interventions