Adiponectin and body mass index relation in CAD with and without type-II DM: A comparative study.

Abstract

Background: The Existing Metabolic disorder like diabetes mellitus, obesity and some other metabolic syndrome have an important risk factor for cardiovascular events, and adiponectin is a key molecule of metabolic disorders, with anti-atherogenic properties. Low plasma adiponectin levels are associated with CAD and future incidence of myocardial infarction. The involvement of adiponectin in coronary plaque vulnerability, which may be reflected by angiographic complex lesions, remains to be elucidated.
Objectives. To study the relationship between adiponectin, body mass index and glycosylated hemoglobin in patients with coronary artery diseases (CAD) with and without type-II diabetes mellitus.
Materials & Methods: - It is a type of observational study among the rural population of kamothe, where a total of 60 subjects were included in the study among which 30 were in CAD with diabetes and 30 in Diabetes mellitus respectively. BMI was calculated by height and weight and HbA1c was measured by HPLC and serum adiponectin level was analyzed by ELISA.
Results: -The mean level of BMI in the group –I that is in the coronary artery disease with diabetes is 24.9±1.24 and in only diabetes subjects is 29.56±1.38 and we have also found the statistical significance (P-0.001). In the regression analysis of adiponectin and BMI and HbA1c, we observed an inverse relationship in both the group whereas in CAD with DM adiponectin was positively correlated with HbA1c (r= 0.56).
Conclusion: - The finding of the present study highlighted that subject with coronary artery diseases with diabetes mellitus had lower adiponectin levels in both the groups