Evaluating the weaning of Septic Patients from Ventilator Support in the Intensive Care Unit: A clinical trial using common Antibiotics
DOI:
https://doi.org/10.48047/Keywords:
Septic patients, ventilator weaning, antibiotic regimens, intensive care unit, tertiary hospital, mechanical ventilation, critical care, antibiotic-related adverse events, patient outcomes.Abstract
Background:
Ventilator weaning in septic patients remains a challenging aspect of critical care management. The appropriate choice of antibiotic regimens can significantly impact patient outcomes during this process. This study aimed to assess the impact of an attention-based
approach to common antibiotic regimens on the weaning of septic patients from ventilator support in a tertiary hospital setting.
Materials and Methods:
A prospective observational study was conducted between October 2022 and March 2023 at a tertiary hospital. A total of 45 septic patients requiring mechanical ventilation were included. Patients were stratified into two groups based on antibiotic management: Group A (attentionbased antibiotic selection) and Group B (conventional antibiotic selection). Data on demographics, clinical parameters, antibiotic regimens, duration of ventilator support, and outcomes were collected. Descriptive statistics and comparative analyses were performed.
Results:
In Group A (n = 22), an attention-based approach to antibiotic regimens resulted in a significantly shorter duration of mechanical ventilation (mean ± SD, 7.4 ± 2.1 days vs. 9.8 ± 2.5 days in Group B, p < 0.05). The rate of successful weaning within 14 days was higher in Group A (77%) compared to Group B (52%). Additionally, Group A exhibited lower rates of antibiotic-related adverse events. No significant differences were observed in mortality rates between the two groups.
Conclusion:
An attention-based approach to common antibiotic regimens in septic patients undergoing ventilator weaning can lead to a shorter duration of mechanical ventilation and a higher rate of successful weaning within 14 days without an increase in mortality. This approach also appears to reduce the risk of antibiotic-related adverse events. Further studies are warranted to validate these findings and refine the antibiotic selection criteria in this context.
