EVALUATION OF SERIAL LACTATE LEVEL IN THE SEVERELY AFFECTED PATIENT’S WITH DENGUE INFECTION AND ITS CORRELATION WITH RENAL DYSFUNCTION: A PROSPECTIVE STUDY

Abstract

Background- Dengue infection has been associated with a variety of renal disorders. Acute renal failure is a potential complication of severe dengue infection and is typically associated with hypotension, rhabdomyolysis, or hemolysis. Acute renal failure occasionally complicates severe dengue infection and carries a high mortality rate. The main aim of this study to identify the correlation between the serum lactate level and renal profile as diagnostic and predictive markers of mortality in the affected patient’s with dengue infection.
Methods - The study enrolled confirmed 132 severe dengue patients that were hospitalized in Index Hospital, Indore (M.P). They were classified into two groups; survivors and non – survivors. Serum lactate was estimated in the interval of 0 hour (on admission) and 24 hours to MICU. The data analysis is expressed as mean and standard deviation (S.D). Statistical comparisons were performed by student t-test using the SPSS 20.0 software. The P value < 0.05 was considered to be statistically significant.
Results: The mean level of serum lactate (5.6 ± 3.69) were significantly higher in the non- survivor group as compare to survivor group. In renal profile, the mean level of urea (68.2 ± 12.8), creatinine (4.2 ± 0.46) were significantly higher in the non- survivors group as compare to survivors group while sodium (128.5 ± 6.75) and potassium (3.21 ± 0.92) levels were found significantly lower in among the groups.
Conclusions: Patients with RF and dengue viral infections have significantly higher risks for DHF / DSS and mortality. Serum lactate level is important predictor of mortality in severely ill dengue patients. The biochemical parameter such as Urea, Creatinine and Uric acid was associated with severity of dengue infection with mortality. Mild hyponatremia and hypokalemia were more common amongst patients of DF as compared to DHF and DSS.