EVALUATION OF LIVER ENZYMES IN CHILDREN WITH DENGUE INFECTIONS
DOI:
https://doi.org/10.48047/Keywords:
dengue infections, alanine transaminase, aspartate transaminase, arthropod borne infections and hepatic dysfunction.Abstract
Background: Dengue virus (DENV), the most important arthropod- borne disease is transmitted to humans by mosquitos of the Aedes family. All four dengue virus serotypes (DENV-1, DENV-2, DENV-3 and DENV-4) can cause the disease which can present as a mild
self-limiting illness, dengue fever (DF), or as the more severe forms of the disease, dengue haemorrhagic fever (DHF) or dengue shock syndrome (DSS). Aim and Objectives: The objectives of our study was to determine the prevalence of hepatic dysfunction in patients with dengue and to correlate between the severity of the disease with the extent of hepatic dysfunction. Materials and Methods: All children with clinical suspicion of dengue fever were screened and only those who were serologically confirmed by NS1 antigen
positivity by Rapid (later confirmed by IgM capture ELISA test) were included. Dengue fever was graded according to National Guidelines of clinical management of Dengue fever, 2015. Besides detailed history, thorough clinical examination and necessary investigations, Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT) was done on day of presentation. Protocol based treatment was given. Statistical analysis was done by chi-square test and Fischer’s exact test wherever necessary. Discussion and Conclusion: Enzyme elevation in Dengue is a common feature. AST elevation was more common than ALT. Highest elevation in liver
enzymes were observed on 5th and 6th day of fever. Liver enzyme elevation was more commonly seen in moderate to severe cases.
