STUDY ON SCREENING FOR GLUCOSE 6 PHOSPHATE DEHYDROGENSASE DEFICIENCY IN NEWBORN BABIES AT OUR TERTIARY CARE HOSPITAL

Abstract

Background: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common human enzyme deficiency in the world. G6PD deficiency is an X-linked disorder affecting mostly African, south east Asian and middle-eastern population. In India, there are 13
biochemical variants of G6PD being reported so far out of which Mediterranean type is most common in the caste groups. Aim and Objectives: to find out the incidence of G6PD deficiency in neonates delivered at our tertiary care hospital and to assess the contribution of G6PD deficiency in causing Neonatal jaundice. Materials and Methods: The study was a prospective hospital based type undertaken among the 400 babies delivered at our hospital from. The objective of this study was to find out incidence of G6PD deficiency in babies delivered in our Hospital and to assess its contribution in causing neonatal jaundice. A detailed antenatal history, consanguinity, geographical area of mother, birth order, mode of delivery, gestational age, birth injuries and blood group were recorded in each baby by interviewing the mother after taking consent in prescribed proforma. The following laboratory investigations
were carried out, G6PD screening test (fluorescent spot test), Baby blood group and Rh typing, Mother blood group and Rh type and If jaundice present total, direct and indirect bilirubin testing was done. If the sample (cord blood) shows G6PD deficiency by fluorescent spot method, quantitative assay was done. Discussion and Conclusion: This study was conducted to detect incidence of G6PD deficiency in neonates and as a contributory factor in neonatal hyperbilirubinemia. The result of this study shows that incidence of G6PD deficiency in neonates delivered at our hospital is 3%. It contributes significantly for Neonatal Jaundice.