Efficacy of Hematological and Biochemical Parameters in Predicting the Severity of Pregnancy Induced Hypertension and Preeclampsia

Abstract

Objectives: Pregnancy-induced hypertension (PIH) is a serious pregnancy complication that contributes significantly to both maternal and neonatal morbidity and mortality. The study aimed to evaluate various hematological and biochemical parameters predictive the severity of PIH and preeclampsia. Methods: This was a cross sectional observational study included the study group (120 preeclampsia patients) and the control group consisted of 120 healthy pregnant women. Venous blood samples were collected to study hematological profile, including coagulation and biochemical analysis.
Results: out of total subjects, 40 were categorized as mild preeclampsia, 80 as severe preeclampsia, and 120 as healthy pregnant women. The mean hemoglobin level and mean platelet count was decreased significantly in Preeclampsia patients as the disease progressed (p<0.05). The mean Prothrombin time and activated partial thromboplastin time were increased significantly in PIH with disease progression (p<0.05). Liver enzymes, creatinine, and uric acid levels increased significantly in preeclampsia as the disease progressed (p<0.05).
Conclusion:. Most of the hematological and biochemical parameters altered as PIH progressed in severity; these indices combined with other parameters can be used in the prediction of preeclampsia.