STUDY OF ASSOCIATION BETWEEN SERUM GAMMA GLUTAMYL TRANSFERASE AND ACUTE ISCHEMIC NON-EMBOLIC STROKE

Abstract

Introduction: Gamma glutamyl transferase is an important enzyme present on cellular membrane in considerable amounts and plays a role in intracellular ingress of amino acids and peptides in the form of gamma glutamyl peptides. Glutathione is its most important substrate. Gamma-glutamyl transferase (GGT) plays key roles in glutathione homeostasis by breaking down extracellular glutathione and providing cysteine, the rate-limiting substrate, for intracellular de novo synthesis of glutathione. Aims: To study the association between serum gamma glutamyl transferase and acute ischemic non-embolic stroke and the association between serum gamma glutamyl transferase and distribution of cerebral infarction areas. Materials and Methods: It is a single centre, hospital based, case control study. This Study was conducted from 1 st March 2020 to 31st August 2021 at Department of N.R.S. Medical College and Hospital, Kolkata (Department of GENERAL MEDICINE – Ward and Out Patient department).
Result: In our study, the distribution of mean serum Total Cholesterol, Triglycerides and LDL Cholesterol between cases and controls was statistically significant (p < 0.0001 for all of the three parameters). However, the distribution of mean serum HDL cholesterol between cases and controls was not statistically significant (p = 0.3651). In Stroke Survivors, the serum GGT level (Mean ± SD) of patients was 64.4737 ± 19.2897 IU/lt. In Stroke Non-survivors, the serum GGT level (Mean ± SD) of patients was 67.8333 ± 16.5471 IU/lt. Distribution of serum GGT level between  Stroke Survivors and Non-survivors was not statistically significant (p-value = 0.5899).
Conclusion: we concluded that. it should be interpreted cautiously as increased serum GGT might reflect an elevated oxidative stress that is only transient at the onset of stroke. Hence further studies, particularly prospective cohort study with large sample size, can help to establish GGT as a predictor for acute ischemic stroke