Study of Diastolic Dysfunction in Normotensive Type 2 Diabetes Mellitus

Abstract

Introduction: Diabetes Mellitus (DM) is one of the largest prevalence disease. It is a chronic progressive metabolic disease, which involves myocardium at relatively early stage even before clinical manifestations become obvious. Myocardial involvement in diabetes may occur early in the course of disease, initially impairing early diastolic relaxation and when more extensive causing decreased myocardial contraction. Material and Methods: This cross sectional study comprised a total 100 cases of type 2 Diabetes Mellitus between age of 30 to 60 years who clinically had no symptoms of cardiovascular involvement and blood pressure <140/90 mm of Hg with normal ECG. The diagnosis of diabetes mellitus was made based on biochemical investigations like fasting blood sugar, postprandial blood sugar and HbA1C and / or past history of diabetes mellitus type 2. Observations were interpreted with p value <0.05 being considered statistically significant
Results: Out of 100 patients, 57 were male and 43 were female patients. Majority of cases were within first 10 years of duration since diabetes detected (84%). Out of 100 cases, 53% had HbA1C level >8 while 12% had HbA1C 6.5-7. Out of 100, 45% (cases) were detected to have diastolic dysfunction. Comparison with other study.
Conclusion: This study showed diabetes as an independent risk factor for diastolic dysfunction. Among 100 cases, 45% had diastolic dysfunction. Among the other variables, Age, duration of diabetes mellitus and HbA1C were found to be associated with diastolic
dysfunction.