Trend Of Haematological Abnormalities Among COVID-19 Patients On Hospital Admission In Northern India.
DOI:
https://doi.org/10.48047/Keywords:
hematological parameters, COVID-19, disease severity, N/L (neutrophil- to- lymphocyte ratio)Abstract
BACKGROUND : COVID-19 is caused by novel severe acute respiratory syndrome corona virus (SARS-CoV-2) which first appeared in December 2019 in Wuhan, China and quickly transformed into a global pandemic. It is a systemic infection with hematological, pulmonary, cardiovascular, gastrointestinal and neurological manifestations. Lymphopenia, eosinopenia, neutrophilia and high N/L ratio are associated with disease progression and severity.
OBJECTIVES: The aim was to study the trend of hematological abnormalities among COVID-19 patients admitted to nodal L3 COVID19 centre.
METHODS: A cross-sectional prospective study was conducted from January to December, 2020. A total of 265 COVID-19 patients were included. Sociodemographic data and disease severity status of admitted patients were recorded. Two milliliters of venous blood was collected and analyzed by Sysmex xs-800i automated analyzer to determine complete blood count (CBC). An odds ratio and 95% confidence interval were used to measure the strength of association. P-value <0.05 was considered as statistically significant.
RESULTS: Of 265 admitted COVID-19 patients, the majority were males (67.5%) and 83% had moderate disease conditions. The common haematological abnormalities found in this study were anemia (75%), lymphopenia (67%), and eosinopenia( 59%), respectively.
CONCLUSION: Hematological abnormalities such as anemia, leukocytosis, neutrophilia, and increased N/L were significantly associated with disease severity. Monitoring and evaluation of hematological parameters could provide prognostic insight into the management and risk stratification of COVID-19 patients.
