ROLE OF ARTERIAL BLOOD GAS ANALYSIS AND SERUM CHOLINESTERASE LEVELS IN PREDICTING OUTCOME OF ACUTE ORGANOPHOSPHORUS POISONING

Abstract

Introduction: There are 3 million acute pesticide poisoning incidents and 3 lakh annual deaths in Asia. Pesticides called organophosphorus compounds are widely utilised, but they pose a serious risk to people because they can be consumed by those trying to kill themselves, inhaled accidentally, or sprayed directly onto skin. Pesticides can be used as biological agents in chemical warfare. Around 60% of self-harm in our nation is done with the intention of poisoning oneself. Most of the time, organophosphorus chemicals account for about 80% of all pesticide toxicity. When determining the prognosis of patients with acute organophosphorus poisoning, ABG measurement is extremely important. Therefore, predictive prognostic features would be helpful for the physicians to stratify the patients according to their likelihood of deterioration. Early identification and vigorous care are frequently lifesaving measures. For patients admitted with OPC poisoning, a variety of clinical and laboratory markers have been utilised to gauge the severity of the poisoning and forecast clinical outcomes like Peradeniya Organophosphorus Poisoning Scale (POPS). To gauge the severity of OP intoxication 1,2 . It was developed by N Senanayake, HJ de Silva, and L Keralliceede at the University of Peradeniya in Sri Lanka. It is a scale that integrates five typical OP poisoning factors (pulse rate, respiratory rate, pupil size, fasciculations, level of consciousness, and seizure activity. 2 Every parameter of POP scale is given score of 0-2 at the time of initial presentation2
. As a result, my research focuses on the relationship between arterial blood gas analysis and serum cholinesterase levels in predicting the prognosis of patients with organophosphorus poisoning as well as the correlation between these variables and the clinical severity Peradeniya organophosphorus poisoning(POP) scale.