A comparative study of Pap smear findings among HIV seropositive women and seronegative Population

Abstract

Background: HIV positive women are more likely than HIV negative women to have cervical dysplasia. Incidence of HPV-related dysplasia increases as immune function declines. This study focuses on the pap smear abnormalities and associated high risk behaviors between seropositive and seronegative women. Methods : The present hospital based a cross-sectional study was
conducted in the Dept of Gynae and Obstetrics, Eden OPD, Medical College and Hospital, Kolkata, West Bengal, India between August 2022 to January 2023. All HIV Seropositive women, attending at Eden OPD during same period after fulfilling the inclusion criteria were included in the study. Statistical data were analysed by using Microsoft Excel and SPSS V.20 software.
Results : Among seropositive women,22%,12%and 2% women tested to have LSIL, HSIL, SCC respectively. 32% women had inflammatory / NILM report. 84% of Seronegative women tested negative for any malignancy and 2(1.3%) patients had ASCUS report. (abnormal squamous cell o undetermined significance).10%,4%,0.7% of the women without HIV reported LSIL, HSIL,SCC respectively.. Association of report in two groups was statistically significant (p<0.0001).
Conclusion : HIV/AIDS is associated with a risk for cervical cytological abnormalities and hence the need for periodic pap smear screening in this high risk group to reduce the global burden of cervical cancer and timely intervention at premalignant stage.