Level of AMHbefore and after Laparoscopic Ovarian Drilling (LOD) in PCOS patients and its effect on fertility.

Abstract

Background
Polycystic Ovarian Syndrome (PCOS) is associated with menstrual irregularities, hyper-androgenism, and polycystic ovaries. Prevalence of PCOS is around 4-18%. PCOS attribute 75% of infertility, due to lack of ovulation. PCOS patients has high level of AMH and in these patients during treatment of infertility there is possibility of developing ovarian hyperstimulation. Laparoscopic ovarian drilling (LOD) frequently performed in PCOS patients, we have decided to compare the level of AMH before and after Laparoscopic Ovarian Drilling (LOD) in these patients and its effect on fertility.
Material & Method
The present study was a cohort study consisting of 88 women with PCOS who underwent laparoscopic ovarian drilling in hitech medical college & hospital Bhubaneswar, odisha in 2021. AMH and estradiol levels of the patients were calculated before the surgery and one week after the surgery. Also, the success rate of fertility was assessed within the twelve months after the surgery, which was indicated by Intrauterine insemination (IUI) or in vitro fertilization (IVF).
Result
The relationship between mean AMH after drilling with BMI category was investigated using a one-way analysis of variance. The results showed that the mean AMH after ovarian drilling was not significantly different in the BMI categories (P =0.181). The relationship between AMH after ovarian drilling with age, BMI and previous menstrual cycle was examined using linear regression. Ageand BMI  variables were not significantly associated with the previous menstrual cycle (P >0.05).
Conclusion
Based on the results of this study, it seems that measuring serum AMH concentration before treatment can be a useful tool in predicting LOD outcomes