COMPARISON OF INTRAVENOUS IRON SUCROSE INFUSION AND INTRAMUSCULAR VITAMIN B12 INJECTION VS INTRAVENOUS IRON SUCROSE IN MANAGEMENT OF IRON DEFICIENCY ANAEMIA IN PREGNANT WOMEN

Abstract

Background-Anemia is defined by World Health Organization as Hb level < 11gm/dl. It is one of the most serious global public health problem affects 52%of pregnant women in developing and 23% in developed countries. The objective of this study was to determine the effectiveness of IV iron sucrose and IM vitamin B12 vs IV iron sucrose in IDA during pregnancy and to determine the safety of IV iron sucrose and vitamin B12 in the treatment of IDA during pregnancy and comparison of side effects in both groups Material and Method – A comparative prospective study, where 200 anemic antenatal women with hemoglobin level of 6.5-8.5 g/dl with microcytic hypochromic anemia having s. ferritin <15 ng/ml were randomized in two groups. This study was carried out in the Department of Obstetrics and Gynaecology, Kamla Raja Hospital, G.R.M.C, Gwalior, M.P. The study was conducted with data collection for a period of November 2020 to October 2022.
Results-The mean baseline s.ferritin is 12.40 ±2.09 and 13.16 ±1.57 in groupA and groups B respectively. Post treatment average rise of s.ferritin is 129.8 and 13.16 in group A and group B respectively (p value 0.0001), which is significant. In our study Hb rise by 3.34gm%
ingroup A and 3.11 gm% in group B which is significant.In our study most of the patients were muligravida.In our study Hb, s ferritin and mcv rises more in group A which receives vitamin B12 as compared to group B[Hb 3.34gm%,mcv-7fl, s.ferritin 129.8mg/l in group A
and in group B Hb3.11gm%,mcv4.74fl,s.ferritin 101.8mg/l
Conclusion- This study concluded that intravenous iron sucrose and intramuscular vitamin B12 is safe, highly efficacious with better compliance for the treatment of iron deficiency anemia in pregnancy. Iron sucrose with vitamin B12 therapy is more effective in achieving the optimum results, an increase in hemoglobin concentration, mean corpuscular volume
levels and an increase in s.ferritin