“Correlation Of Leptin And Adiponectin As A Promising Marker In Obese And Non Obese Women With Polycystic Ovary Syndrome Patients At A Tertiary Care Centre, Uttar Pradesh, India”

Abstract

Background:Polycystic ovary syndrome (PCOS) is a common, complex and heterogeneous reproductive endocrinopathy of females throughout the world. Circulating leptin correlates strongly with obesity, which is frequently associated with polycystic ovarian syndrome (PCOS), Adiponectin is a circulating protein produced by adipocytes. Circulating levels of adiponectin are inversely
related to adipocyte mass. Aim and Objective: To Study the Association of Leptin and Adiponectin as a predictive marker in Obese And non Obese Women with Polycystic Ovary Syndrome Patients. Material and Methods:This was a case control study carried out in the Department of Biochemistry with collaboration with the Obstetrics and gynaecology Department. The study comprised of 120 patients with PCOS and 120 controls without PCOS.Each group was analysed for the following parameters as TSH,Prolactin,FSH, LH,AMH, Total
cholesterol,Systolic/diastolic(BP),BMI,Leptin, Adiponectin ,MDA(Malondialdehyde) and SOD( Superoxide dismutase).The validity of leptin toward the diagnosis of PCOS or leptin combined with these parameters was estimated by Descriptive and inferential statistical analysis at 5% level of significance.
Results: In the present study increased level of leptin among women with PCOS positively associated with FSH, LH, TSH, Total cholesterol, MDA in PCOS whereas Adiponectin was negatively correlated. However, there was no statistically significant correlation between the Adiponectin Insulin and the Body Mass index with respect to PCOS.
Conclusion:The relationships between leptin and adiponectin and insulin resistance and sensitivity, metabolic syndrome, and BMI in women with PCOS suggest that Leptin and Adiponectin potentially could serve as a marker for disease risk and provide opportunity for earlier intervention if knowledge is successfully translated from laboratory to clinical practice. However, further study of the relationship between adiponectin and PCOS is required before there can be direct application to clinical practice.