I.V. esmolol hydrochloride and I.V. clonidine: Blood pressure changes in response to laryngoscopy and intubation

Abstract

Intravenous anaesthetic induction agents alone do not adequately suppress the circulatory responses evolved by endotracheal intubation therefore prior to initiating laryngoscopy and endotracheal intubation additional pharmacological measures should be taken. A clinical comparative single blinded study of attenuation of sympathetic response to laryngoscopy and intubation was done in 90patients posted for elective surgeries selected randomly. Patients undergoing various Orthopaedic, ENT, and General surgical procedures were selected. We observed in our study, in the control group systolic blood pressure increased maximally after 1 minute from onset of laryngoscopy and intubation and then it gradually decreased to preinduction level over 10 minutes. When we compare esmolol, we found statistical significant difference of a higher fall of the systolic blood pressure in clonidine groups