Cross-Sectional Analysis of Brain MRI Findings in Patients with Alzheimer's Disease

Abstract

Background: Alzheimer's Disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment. Brain Magnetic Resonance Imaging (MRI) has emerged as a crucial tool in identifying the neuroanatomical changes associated with AD. This study aims to analyze the MRI findings in AD patients, focusing on specific brain regions commonly affected by the disease. Methods: In this cross-sectional study, brain MRIs of 200 patients diagnosed with Alzheimer's Disease were analyzed. Patients were recruited from neurology clinics and underwent high-resolution MRI scanning. The study focused on quantifying volumetric changes in the hippocampus, amygdala, and cortical areas. Additionally, the severity of AD was assessed using established clinical scales.

Results: The analysis revealed significant atrophy in the hippocampus and certain cortical areas, with a pronounced correlation between the extent of atrophy and the clinical severity of AD. The amygdala showed less significant changes. These findings align with the current understanding of AD pathology and suggest that MRI can be a valuable tool in diagnosing and assessing the progression of the disease. Conclusion: This study provides valuable insights into the brain morphology changes in
Alzheimer's Disease patients and reinforces the role of MRI as a diagnostic and monitoring tool in clinical practice. Further research, including longitudinal studies, is needed to expand upon these findings