The Association Between Serum Lipids Level And Colorectal Neoplasm: a Cross-Sectional Study in a Tertiary Health Care
DOI:
https://doi.org/10.48047/Keywords:
Serum total cholesterol (TC), High density lipoprotein cholesterol (HDL- C), VLDL cholesterol (VLDL-C), LDL cholesterol (LDL-C), Tri- glycerides (TG)Abstract
INTRODUCTION Colorectal Carcinoma is the fourth most common cause of cancer death all around the world. In different literature, some consider serum lipid profile is one of the etiological risk factor among other risk factor. So estimation of serum lipid in this disease can link the association of healthy diet and colorectal Carcinoma.
OBJECTIVE To study in detail the relationship between serum lipids level and the outcome in colorectal carcinoma and thereby to find any clue to prevent this malignant disease.
METHODS AND MATERIALS The study was done in patients who are admitted in the department of General Surgery VIMSAR, Burla from December 2020 to October 2022 in two groups. 40 cases of diagnosed with carcinoma of different parts of the colon and rectum on different stages and of different age groups were selected randomly as case group and 40 cases of patient suffering from other diseases but not colorectal carcinoma were taken as controls group. The serum TC,HDL-C,VLDL-C,LDL-C,TG were estimated from both case and control group for compared and analysed.
RESULTS-
A decrease in serum levels of TC, TG and LDL-C was seen in tumour group as against the levels in the control group irrespective of sex, location and stage of the malignancy. But, significant difference was seen in the serum levels of above parameters in advanced cases
only comprising Dukes’ C1 and C2, and on site comparison right sided cases were significantly lower than the left sided carcinomas and the decrease in the level of serum TC was statistically significant. CONCLUSIONThere is an inverse correlation between colorectal carcinoma and serum TC, TG and LDL- C levels. It may be utilized for follow-up of treating colorectal carcinoma cases and also a low
level of these serum parameters preceding the disease or in early tumours, may be exploited on screening the cases, so that a more curative approach in treating this dreaded disease may be planned. As our study consists of a Small number of participants, it needs
further through investigations and a population based cohort study for further clarification of this relationship.
