“Study of antioxidant and lipid peroxidation status among postmenopausal women''

Abstract

Present study was conducted in Department of Biochemistry Dr. SCGMC Nanded over the period of 18 months. Well informed written consent was taken from every study subject and it was ethically cleared from the institutional ethical committee. Study subjects includes 50 healthy premenopausal and 50 healthy postmenopausal women. We have studied the antioxidant status my measuring the values of antioxidant enzymes as glutathione peroxidase (GPx) and superoxide dismutase (SOD). Lipid peroxidation status was studied by measuring the malondialdehyde (MDA) level. One-way ANOVA was used for statistical analysis. We observed that the mean glutathione peroxidase (GPx) and superoxide dismutase (SOD) levels were decreasing from premenopausal to early postmenopausal and late postmenopausal women and mean MDA levels were increasing from premenopausal to early postmenopausal to late postmenopausal. The p value was<0.0001 and was statistically significant. At the end we conclude that in postmenopausal women the antioxidant defense decreases and oxidative stress increases as compared to premenopausal women and these parameters are directly proportional to menopausal duration