Association of insulin resistance with Vitamin-D in diabetic patients with or without microvascular disease

Abstract

Background: T2DM and vitamin D insufficiency share risk factors such as American-African ancestry, obesity, ageing, and poor physical activity. There is also evidence linking vitamin D insufficiency to illnesses such as osteoporosis, cardiovascular disease, and metabolic syndrome problems. Objective: This study aimed to investigate the impact of vitamin D supplementation on insulin resistance in individuals with T2DM. Material and Method: The present study was conducted in the Department of Biochemistry. A total of 600 subjects were included in this study, which further divided into three groups (control, T2DM without microvascular complications, and T2DM with microvascular complications) SPSS software is used for statistical calculation.
Result: The difference in Vitamin D level between control and group-I is significant (P =0.044) while the difference between control and group-II is statistically significant (P=0.001). In addition, the comparison of study group-I and study group-II is statistically significant p=0.001 and mean difference is 3.69.
Conclusion: Vitamin D appears to help diabetes management, and vitamin D supplementation is advised as part of the treatment for type 2 diabetes