Serum Alfa Feto Protein and Protein Induced By Vitamin K Absence-II (PIVKA-II) Combined Strategy for a Better Diagnosis of Hepatocellular Carcinoma
DOI:
https://doi.org/10.48047/Keywords:
Hepatocellular carcinoma (HCC), Alfa-Fetoprotein (AFP), Prothrombin induced by vitamin K absence or antagonist-II (PIVKA-II).Abstract
Background
Hepatocellular Carcinoma (HCC) is conventionally diagnosed using serum alfa-fetoprotein (AFP). Prothrombin induced by vitamin K deficiency or antagonist- II (PIVKA-II) is another potential biomarker described in many studies. Neither of the biomarkers have been found to be efficient. The possibility of augmenting the diagnosis of HCC when both these tumour markers measured simultaneously needs to be evaluated.
Methods
Patients with biopsy proven HCC were taken for the study. Serum AFP and PIVKA II measurements were recorded in these patients. Radiology examination with CT Scan or MRI scan was grouped as typical or Atypical features of HCC.
Results
32 patients had biopsy proven HCC. AFP was elevated in 22 (68.8%) patients. PIVKA-II was elevated in 21 (65.6%) patients. Combined AFP and PIVKA-II was elevated in (90.6%).
Conclusions
Combined efficacy of doing both S.AFP & S. PVIKA-II is better than doing either S.AFP or S. PVIKA-II.
