To study Characterizing of Early Leprosy by routine histopathology Immunochemistry and by methods of Molecular Biological

Abstract

Background & Methods: The aim of the study is to study Characterizing of Early Leprosy by routine histopathology Immunochemistry and by methods of Molecular Biological.
Results: The lesions were found to be mostly in the extremities (44/50, 88%) with the upper extremities being more frequently involved. Nerve thickening was observed to be present in 26% of the cases, with cutaneous nerve involvement being seen in 5 (10%) and peripheral nerve trunk involvement in 8 (16%). The skin smear was negative for AFB in all, and the Mitsuda lepromin reaction was positive in 18/30 (60%) of the cases studied.
Conclusion: The present study, 100 cases of clinically diagnosed early leprosy (Idt leprosy, early TT/BT) and, 90 cases of clinically suspect leprosy were studied from the viewpoint of histological diagnosis. Homogeneity within the two groups was achieved by selecting only untreated cases and by defining the features required to make the clinical diagnosis. Biopsies were taken from the lesion peripheries, fixed in 10% buffered formalin, and, processed for routine histopathological examination. The histological diagnosis of leprosy, using specific defined criteria was made in (36%) in the clinical category of early leprosy, and in (24.44%) in the clinical category of suspect leprosy. These findings are consistent with the low (and variable) degree of histological confirmation reported in several studies in the chosen categories of cases.