Histomorphological evaluation and classification of carcinoma of breast

Abstract

Invasive carcinoma of no special type(NST) and invasive lobular carcinoma (ILC) are the two most common histological subtypes of invasive breast cancer, with Invasive Carcinoma NST occurring in more than three- quarters of patients. ILC has distinct biologic and prognostic features. Compared with Invasive Carcinoma NST, ILC is less frequent in patients under 35 years of age and associated with more bilaterality advanced tumor stage and nodal involvement. The study has been conducted in the Department of Pathology, in cooperation with the Department of General Surgery. The study material included all the breast specimens (n=180) received as modified radical mastectomy with exclusion criteria of post radiotherapy and post chemotherapy in histologically proven cases of carcinoma of the breast. In the present study, Elston & Ellis modified Bloom & Richardson system was applied for grading of ICNST. Of the 128 cases of ICNST, the majority were of grade II with 60.3% (77/128) followed by grade III with 27% (35/128) and grade I with 12.7% (16/128).