Assessment of Hepatic Involvement Through Liver Function Tests in Dengue Patients: A Cross-Sectional Study at a Tertiary Care Hospital in Southern Odisha
DOI:
https://doi.org/10.48047/Keywords:
Dengue, Hepatic Manifestations, Liver Function Tests, AST, ALT, SGOT, SGPT, Tertiary Care Hospital, South Odisha, Cross-Sectional Study.Abstract
Background: Dengue, a vector-borne viral disease, poses a significant public health challenge, especially in South Odisha. This cross-sectional study, conducted at SLN Medical College Hospital, Koraput, Odisha, focuses on evaluating liver function tests in 100 Dengue patients. Acknowledging the importance of hepatic involvement in Dengue, the research aims to provide valuable insights into the manifestations of the disease, potentially enhancing diagnostic and management strategies in the region.
Methodology: Employing a systematic approach, this cross-sectional study enrolled 100 Dengue patients at SLN Medical College Hospital, Koraput, Odisha. Standardized liver function tests, including serum bilirubin, alanine transaminase (ALT), aspartate transaminase (AST), and alkaline phosphatase, were conducted. Data analysis involved descriptive statistics, offering a comprehensive overview of hepatic parameters in Dengue patients within this tertiary care setting.
Results: Among the Dengue patients, 40% exhibited less than a 2-fold increase in AST levels, 28% showed a 2-10-fold rise, and 10% demonstrated more than a 10-fold increase. Overall, 22% maintained normal SGOT values, with 78% displaying elevated levels. Regarding SGPT, 20% had normal values, 35% presented with less than a 2-fold increase, 25% displayed a 2-10-fold rise, and 20% had more than a 10-fold increase from normal levels. Early-stage symptoms like vomiting and abdominal pain correlated with hepatic involvement, with statistically higher AST and ALT levels in patients developing complications such as DHF, DSS, hepatic failure, ARDS, AKI, and encephalopathy.
Conclusion: This study highlights a notable prevalence of hepatic involvement in Dengue patients, underscoring the significance of vigilant monitoring, especially in cases with early symptoms and those at risk of complications. These findings offer crucial insights for tailored interventions and enhanced patient care within the tertiary care context of South Odisha.
