Effectiveness of magnesium sulphate as an adjunct to ropivacaine in local infiltration for postoperative analgesia following lower segmental caesarean section

Abstract

Magnesium (Mg) is a physiological blocker of calcium channels and a non- competitive antagonist of Nmethyl di aspartate (NMDA) receptors, which can relieve pain by inhibiting central sensitization to pain. Magnesium Sulphate (MgSO4) infusion during general anaesthesia decreased the need for intraoperative and postoperative analgesics, and other studies suggested that Mg administration affected the postoperative pain. The minimum sample size is 57. So, we included 60 patients considering few dropouts. We included 30 patients in each group. There is significant difference statistically in the mean VAS score in between two groups for 4th time pain reported. It was 3.86 in group R and 0 in group RM. This implies that RM is more effective than R. There is no significant variation statistically in the incidence of adverse drug reactions of both groups. Headache was seen in 3 patients and nausea ,vomiting was seen in 8 patients