A COMPARISION OF MIDAZOLAM CO-INDUCTION WITH PROPOFOL PREDOSING FOR INDUCTION OF ANAESTHESIA

Abstract

Background: Anaesthetic technique used for any surgery in adults comprises of induction with Intravenous (IV) anaesthetic drugs. When induction agent like propofol is combined with a sedative like midazolam, synergism occurs between these two drugs causing reduction in total dose of primary drug like propofol, a technique called co-induction.
1. INTRODUCTION
The term co-induction has been used to describe the practice of administering a small dose of sedative or another [1] anaesthetic agent to reduce the dose of induction agent required.The term was coined in 1986. Currently, has become increasingly popular.
Anesthesiologists use intentional co-induction of anaesthesia to take advantage of medication interactions, particularly synergism. Midazolam has been proven to minimize the amount of propofol required to produce anaesthesia by up to 50% without compromising the recovery profile when administered in this fashion [4].
Objectives: The aim of this study is to evaluate the midazolam co-induction and propofol predosing for induction of anaesthesia with regard to dose and hemodynamic variability