HLA-DQ2 and HLA-DQ8 Genotyping in Indian Celiac disease Patients and Their First-Degree Relatives

Abstract

Background and Aim: Celiac disease is a human leukocyte antigen (HLA)
associated disease. Approximately 90% to 95% of patients with celiac disease carry the HLA-DQ2 allele and
the remaining 5% to 10% carry the HLA-DQ8 allele. Single centre
observational study was carried out to determine the role of HLA DQ2/8 testing in screening of first-degree
relatives of patients with Celiac disease.
Methods: fifty confirmed patients with Celiac disease and 146 first-degree relatives (parents and siblings) were
enrolled. HLA DQ2/8 testing was carried out in all index Celiac disease cases. Clinical evaluation with human
Ig A-tissue transglutaminase ( Ig A- T tG) and HLA DQ2/8 testing was carried out in all first-degree relatives.
Those patients are positive for IgA-TtG were recommended UGI endoscopy and biopsy to document
histological changes of Celiac disease