“Study of serum antioxidants and C-reactive protein level in preeclampsia.”

Abstract

Present study was conducted in Department of Biochemistry Dr. SCGMC Nanded over the period of 18 months. Well informed written consent was taken from every study subject and it was ethically cleared from the institutional ethical committee. The study population consisted of 120 pregnant women, of whom 60 were normal pregnant healthy women taken as control and 60 pregnant women with diagnosis of Preeclampsia were taken as cases. The cases were divided in two groups as mild and severe cases of preeclampsia. Measurement of inflammatory marker like C-reactive protein, measurement of lipid peroxidation markers like serum malondialdehyde.
And for oxidative stress serum superoxide dismutase, serum uric acid and Vitamin C were measured among the study subject.
Serum CRP was found to be significantly increased with the severity of preeclampsia in mild and severe cases when compared with normal pregnant women. High levels of CRP in preeclampsia highlight the underlying pathogenesis of endothelial inflammation and disease progression. Serum MDA levels was also found to be significantly increased with the severity of preeclampsia in mild and severe cases when compared to controls. This rise was because of the increased oxidative stress in preeclampsia resulting in higher lipid peroxidation. Also, antioxidants like serum SOD and Vit C were decreased with the severity of preeclampsia as compared to controls indicating their increased turnover for the prevention of oxidative damage and lipid per-oxidation.. In contrast serum uric acid was shown to be increased with the severity of pre-eclampsia in mild and severe cases when compared to controls. Increase in the levels of serum uric acid was mainly because of decreased urate excretion commonly found in preeclamptic women.