A COMPARATIVE STUDY TO EVALUATE THE ASSOCIATION BETWEEN SERUM LIPID PROFILE OF WOMEN WITH HYPERTENSIVE DISORDER OF PREGNANCY AND NORMOTENSIVE PREGNANCY

Abstract

Background: Hypertensive disorders of pregnancy constitute one of the members of deadly triad of maternal death – along with hemorrhage and infection. It is postulated that the alteration of lipid metabolism may play a key role in the development of symptoms of PE and eclampsia. Materials and methods: It is a prospective case-control study. 50 normotensive pregnant women were selected as controls and 50 pregnant women with hypertensive disorders of pregnancy were selected as cases as per inclusion and exclusion criteria. A 5ml of fasting venous blood Samples were collected and lipid profile was done. Objective: To evaluate the association between serum lipid profile of women with hypertensive disorder of pregnancy and normotensive pregnancy. Results: There was significant rise in the values of Serum Triglycerides(TG), Low density Lipoprotein-C(LDL-C), Very Low Density Lipoprotein-C(VLDL-C) in the hypertensive disorder of pregnancy group compared to normotensive group. Conclusion: Pregnant women with hypertensive disorder of pregnancy have deranged serum lipid profile when compared to normotensive pregnant women. Dyslipidaemia play certain role in the pathogenesis of hypertensive disorder of pregnancy. Lipid profile can be used as a tool for the detection and management of Hypertensive disorder of pregnancy.