EFFICACY OF GATA3 EXPRESSION IN BREAST CARCINOMA TISSUE FOLLOWING NEOADJUVANT CHEMOTHERAPY

Abstract

Background: Breast cancer is a leading cause of cancer-related mortality in women, with a
rising incidence globally. Neoadjuvant chemotherapy(NACT) is a standard treatment
approach for operable advanced loco-regional breast cancer, aiming to achieve tumor
shrinkage, downstaging, and improved surgical outcomes. GATA3 expression has been
identified as a significant marker for tumor differentiation, estrogen receptor status, and
clinical outcomes in breast cancer.