RENAL IMPAIRMENT ASSOCIATED WITH DIFFERENT PULMONARY ARTERIAL HYPERTENSION STAGES

Abstract

Background: An imbalance between the processes of vasoconstriction and vasodilation characterizes pulmonary arterial hypertension, a multiple pathobiology and complicated and interdisciplinary illness.
Aim: The objective of our research was to determine the prevalence of pulmonary arterial hypertension (PAH) in individuals with chronic kidney disease (CKD) and investigate the correlation between PAH and different phases of CKD.
Methods: A cross-sectional hospital-based study including 60 CKD patients was carried out between December 2020 and June 2022. With the use of 2D echocardiography, pulmonary arterial pressures were determined, and MS Excel was used to evaluate the results.
Results: Between CKD patients, the mean pulmonary artery systolic pressure (PASP) was 50.83 ± 9.779 mmHg, and the prevalence of PAH was 86.7%. The prevalence of PH increased as CKD stage advanced. Diabetes and hypertension had a strong association with
PH (59.6% & 92.3%). Compared to individuals receiving conservative therapy, the prevalence of PH in hemodialysis (HD) patients (63.5%) was significantly higher. those on dialysis with an arterio-venous fistula had a pulmonary arterial pressure that was substantially greater (44.2%) (p < 0.001) than those using a femoral or jugular vein HD catheter.
Conclusion: Individuals with chronic kidney disease had a notable incidence of PAH. When compared to patients who used a femoral or jugular vein HD catheter, patients undergoing dialysis via an arterio-venous fistula exhibited noticeably elevated pulmonary arterial
pressures. The most frequent etiological variables for chronic renal disease in our research were diabetes and hypertension.