Cross sectional study to determine clinical and immunological profile of Mixed connective tissue disorder cases in a tertiary care center

Abstract

Background: Mixed connective tissue disease is a rare autoimmune disease, characterized by the production of specific autoantibody anti-RNP, which presents with varied overlapping symptoms of different connective tissue disorders. The aim of this study is to identify the frequency and patterns of MCTD.
Objective :To study the clinical profile and immunological profile of MCTD patients and adverse events developed during the duration of treatment
Design :Cross sectional study
Setting : A large, academic, tertiary medical center
Methodology:All MCTD cases admitted in Sapthagiri Institute of Medical Sciences and Research Centre was included.Data was collected through a prepared performa.Patients were followed up till death or discharge.
Results:All 30 cases of MCTD, U1RNP is positive.