Serum AMH (Anti-Müllerian Hormone) as a predictor of Polycystic Ovarian Syndrome among the Women of Reproductive Age – a study in a tertiary care hospital

Abstract

Background: Anti-Müllerian Hormone (AMH) is multiple fold increased in PCOS women compared to normal women. The increase in AMH is due to an increase in the number of antral follicles which increases in response to gonadotropin hormone. This study aims to determine the specificity and sensitivity of AMH in the diagnosis of polycystic ovarian syndrome.
Method: A cross-sectional study was carried out. 100 women diagnosed with PCOS participated in the study. They were examined for their reproductive characteristics and demographic characteristics. The AMH levels were assessed in these women with an immunoassay. The correlation between the levels of AMH and reproductive characteristics was determined statistically.
Results: It was found that the number of days in the menstrual cycle, volume of the left ovary, and level of luteinizing hormone were significantly different in both types of women. Hence, the p-value for the menstrual cycle, volume of the left ovary, and level of luteinizing hormone were 0.03, 0.05 and 0.01, respectively, when correlated with the levels of anti-Müllerian hormone.
Conclusion: Assessment of AMH levels can aid in the diagnosis of PCOS. Increased levels of AMH indicate hormonal imbalance, irregularities in the menstrual cycle and polycystic morphology of the ovary. These three characteristics are often associated with polycystic ovarian syndrome