A clinical study of the patients suffering from Herpes Zoster (Shingles) in correlation with cardiovascular diseases
DOI:
https://doi.org/10.48047/Keywords:
: Herpes zoster, cardio vascular diseases, cardio vascular diseases risk, Acute myocardial infarction (AMI), stroke, Percutaneous coronary intervention(PCI).Abstract
Background: The basis for increased cardiovascular events following acute infection is hypothesized to be endothelial dysfunction, characterized by atheromatous plaque rupture and the development of a prothrombotic environment . As acute cardiovascular diseases (CVDs), specifically ischemic stroke and MI, are major causes of morbidity and mortality in the India and worldwide, understanding the basis for acute cardiovascular events and any potential for prevention becomes increasingly important.
Aims and Objectives: To analyze the patients suffering from Herpes Zoster (Shingles) in correlation with cardiovascular diseases.
Materials and Methods: Retrospective study was performed in our private clinics as well as in the department of Dermatology, General Medicine, Cardiology and Neuro-medicine, Santiniketan Medical College and Hospital, Bolpur, Birbhum, West Bengal, India. Sample subjects were 200, distributed in 2 separate group, Non HZ group and HZ group, 100 subjects in each group.
Results and Observations: Overall, 200 subjects were diagnosed with HZ during the study period, 200 patients were included in this study (100 patients per group). The average age at zoster diagnosis was 45.7 (±18.0) years. Of these patients, 33.8 were male, 18% had diabetes mellitus, and 30.5% had hypertension as underlying diagnoses. The follow-up period did not differ significantly between the study groups, with a minimum of 0 and a maximum of 5 years, and a mean follow-up interval of 1.5 years. Cumulative MACCE survival at the end of the follow-up period was 54% in the HZ group as compared to 74% in the non-HZ group (P<0.001)
