STUDY OF SERUM hsCRP ACTIVITY LEVEL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS WITH GOOD AND POOR GLYCAEMIC CONTROL

Abstract

Background
Diabetes mellitus comprises а group of common metabolic disorders which shаre common phenotype of hyperglycemiа.CRP which has both proinflammatory and anti-inflammatory property and is a direct contributor to atherosclerosis with introduction of high sensitive CRP assays which is a most potent independent predictor of atherosclerosis and coronary artery disease.CRP level, which significantly increаses in аcute coronаry syndromes, hаs а prognostic vаlue in pаtients with cаrdiovаsculаr complicаtions аnd in аppаrently heаlthy individuаls.The importance of CRP in the pathophysiology of atherosclerosis, including the potentiаl mechanisms of аction in circulation as well as the potentiаl impact of genetic vаriаtions within the CRP gene, The ability of human CRP to activate/regulate complement could be a crucial charаcteristic that connects CRP and inflammation to atherosclerosis.
METHODOLOGY
Prospective observational study.Patients with clinical features of diabetes mellitus admitted in medicine department, KIMS will be taken for study. 210 patients presenting with history ,characterstic clinical signs and symptoms of diabetes mellitus are taken into study and the following investigation will be done in selected patients.A study consists of 210 subjects,out of them 70 patients having type 2 DM with good glycemic control (Group 2),70 patients with type 2 DM with poor glycemic control and 70 normal healthy control (Group1) were selected.
Result
The mean (SD) of hsCRP (mg/L) in the Group: 1 group was 2.04 (1.51). The mean (SD) of hsCRP (mg/L) in the Group: 2 group was 5.20 (10.93). The mean (SD) of hsCRP (mg/L) in the Group: 3 group was 16.91 (19.12). The median (IQR) of hsCRP (mg/L) in the Group: 1 group was 1.86 (1.2-2.68). The median (IQR) of hsCRP (mg/L) in the Group: 2 group was 2.54 (1.79-3.26). The median (IQR) of hsCRP (mg/L) in the Group: 3 group was 5.85 (3.44-29.6). The hsCRP (mg/L) in the Group: 1 ranged from 0.34 - 9.1. The hsCRP (mg/L) in the Group: 2 ranged from 0.45 - 66. The hsCRP (mg/L) in the Group: 3 ranged from 2.12 - 76.8. There was a significant difference between the 3 groups in terms of hsCRP (mg/L) (χ2 = 90.513, p = <0.001), with the median hsCRP (mg/L) being highest in the Group: 3 group.
Conclusion
There was positive correlation between FBS, PPBS, HbA1c and GGT,FBS, PPBS, HbA1c and hsCRP, indicating increasing oxidative stress and inflammation in patients poor glycemic control in Diabetes Mellitus. There was positive correlation between GGT and hsCRPin Diabetes Mellitus indicating linear relation between oxidative stress andinflammation.