TO STUDY THE LEVELS OF HBA1C AND IT IS PROGNOSTIC IMPORTANCE IN THE ACUTE CORONARY ARTERY DISEASE IN TYPE-2 DIABETICS POPULATION
DOI:
https://doi.org/10.48047/Keywords:
HbA1c (Glycosylated haemoglobin) Type 2 DM (Type 2 Diabetes Mellitus), ACS, (Acute Coronary Syndrome), CAD (coronary artery disease), CPK-MB (Creatine Phosphokinase), ECG (Electrocardiography), MI (Myocardial Infarction), CHD (coronary heart disease), NSTEMI (non-ST elevation Myocardial infection.Abstract
Background: It is believed that chronic hyperglycemia (assessed by glycosylated haemoglobin levels) is related to the development of microvascular disease. Since Mortality due to coronary heart disease is very high in diabetics, it is imperative to understand the relation of increased levels of HbA1c in patients of acute myocardial infarction.
Aims: To study the levels of HbA1c and it is prognostic importance in the acute coronary artery disease in type-2 Diabetics population.
Material And Method: The study was conducted on 60 patients admitted were divided into 2 groups of 30 patients each. Group A: Type 2 Diabetes Mellitus with acute myocardial infarction. And Group B: Non diabetic patients of age and gender matched with acute
myocardial infarction as control in the department of medicine Rajindra Hospital and Govt. Medical college Patiala and the biochemical investigations were conducted in the department of biochemistry Govt. Medical college Patiala and the results were Statistically analysed.
Result: The mean value of HbA1c was found 8.27+ 1.22 % in the group A patients and mean value of HbA1c 5.79 + 0.50% was found in the group B patients. Out of the 30 diabetic patients presenting with acute myocardial infarction, 23 (76.66%) had a poor glycemic control, as evidenced by HbA1c levels > 7%. Poor glycemic control among the diabetics (HbA1C > 7%) were found to have a significant positive correlation with Myocardial dysfunction (systolic and diastolic) and Heart failure
Conclusion: In conclusion, our study results show a significant association of glycemic control, measured by HbA1C levels. The Study shows that patients with DM when compared to nondiabetics have increased morbidity and severity after acute myocardial infarction.
