A CASE CONTROL STUDY OF CORRELATION OF VITAMIN D LEVEL WITH SEVERITY OF OSTEOPOROSIS AND EVALUATION OF EffECT OF VITAMIN D SUPPLEMENTATION IN TREATMENT OF OSTEOPOROSIS IN ELDERLY

Abstract

Background: Osteoporosis poses a significant public health concern globally, particularly among aging populations. Vitamin D deficiency has been implicated as a contributing factor to bone mineral density (BMD) loss and osteoporotic fractures, although the efficacy of vitamin D supplementation remains debated. This study aimed to investigate the association between vitamin D status and BMD in elderly individuals with osteoporosis, as well as the impact of vitamin D supplementation on treatment outcomes.
Methods: A case-control study was conducted among elderly patients diagnosed with primary osteoporosis, assessing vitamin D levels, dietary intake, sun exposure, and BMD using Dual Energy X-ray Absorptiometry (DEXA). Patients were randomly assigned to
receive either standard osteoporosis treatment alone or with additional vitamin D supplementation. Changes in BMD and vitamin D levels were monitored over 12 months.
Results: The study found no significant differences in baseline T-scores or vitamin D levels between the supplemented and control groups. However, after 12 months, the supplemented group showed significantly higher vitamin D levels compared to the control group (p < 0.001). While there was no significant difference in T-scores between the groups at 12 months (p = 0.199), qualitative analysis revealed a notable reduction in osteoporotic BMD status in the supplemented group compared to controls (5% vs. 35%).
Conclusion: Vitamin D supplementation demonstrated a positive impact on vitamin D levels and qualitative improvement in BMD status among elderly individuals with osteoporosis. Although no significant difference in T-scores was observed between groups at 12 months, the study highlights the potential benefits of vitamin D supplementation in accelerating the therapeutic process and improving bone health in this population. Further research with larger sample sizes and longer follow-up periods is warranted to confirm these findings and assess long-term treatment outcomes.