TYPE 2 DIABETES MELLITUS AND SERUM URIC ACID AS AN INDICATOR OF CORONARY ARTERY DISEASE: A CROSS-SECTIONAL STUDY

Abstract

Background and Objectives: One of the symptoms of Type-2 diabetes mellitus Syndrome X is hyperuricemia. However, the precise pathophysiology of coronary heart disease and uric acid is unknown. The study's objective was to determine whether higher serum uric acid concentrations in type 2 diabetic patients are indicative of coronary artery disease.
Material and Methods: This study was conducted at the Department of Biochemistry, GMC, Mahabubabad, Telangana, India between October 2022 to September 2023. The study comprised around 83 patients, with 7 being eliminated due to the presence of ischemia alterations exclusively in the ECG. The study had two groups of individuals, all of whom had diabetes. Another group consisted of patients who had clinical and electrocardiographic indications of prior myocardial infarction.
Results: Diabetic patients with coronary artery disease had notably elevated blood levels of inflammatory biomarkers and oxidative malondialdehyde. Conversely, they displayed considerably reduced levels of serum total antioxidant capacity compared to both the control group and diabetic patients without CAD. There were strong positive associations between levels of serum uric acid and levels of inflammatory biomarkers and malondialdehyde. Conversely, there was a significant negative link between SUA levels and total antioxidant capacity in the serum. SUA exhibited a proficient capacity to discern and differentiate.
Conclusions: Our results show that triglyceride levels are much higher in people with coronary heart disease compared to those without the condition. Additionally, hypertriglyceridemia has been linked to increased uric acid levels